Recent research into medullary thyroid cancer (MTC) is looking into new ways to treat the disease. The investigational treatment we are studying is a newer type of chemotherapy called targeted therapy. The aim of our study is to compare the safety and effectiveness of the investigational medication with that of the standard treatment for medullary thyroid cancer, which is traditional oral chemotherapy.
Participants will be randomized into two study groups with a 2:1 ratio. This means that at the beginning of the study, volunteers have a 66% chance of receiving the study drug, and a 33% chance of receiving a standard therapy, either cabozantinib or vandetanib. Patients receiving cabozantinib or vandetanib may be eligible to receive the study drug later in the trial. Read more about this study’s treatment groups in the Frequently Asked Questions section below.
This study is not using a placebo.
Phase 3 research studies are the third step in a four-step drug approval process. In this phase, scientists test whether an investigational medication is more effective than the standard treatment in people with a specific disease or condition. Phase 3 studies often include around 300-3000 volunteers that have the disease or condition being studied.
You may qualify for this research study if you meet the criteria listed below. You can learn if you qualify after you indicate your interest in the study.
Thyroid cancer that cannot be removed by surgery or has spread to other places in the body.
No prior treatment with kinase inhibitors and evidence that the cancer has gotten bigger in the last 14 months.
Evidence that your cancer is caused by a mutation in the RET gene.
The first two months of study appointments are shown in the graphic. However, you can participate for as long as you and your doctor think you are benefitting from study participation.
Each appointment is a little different. For example, you may engage in any of these activities at a visit:
Researchers in over 100 sites globally are looking for volunteers for this research study.
Use the map or table below to find a participating site near you and call them for more information.
|Research Site Name||City||State||Phone Number|
Locate participating research sites in your area using the map or table in the Locations section above. Then choose your preferred research site. To use the map, select a pin to display the site contact information. To use the table, simply browse the results for contact information. You can also filter results using the search box if you’d like.
Call your preferred research site. The research site staff will tell you more about the research study, and answer any questions you may have. They will also ask you questions to assess your fit for the research study. If you are interested in the clinical trial, and seem eligible to participate, research study staff will schedule a time to further assess your fit for the research study.
During your appointment, the research study staff will continue to assess your fit for the study. They will also give you important research study information, like the schedule of appointments and the possible risks of participation. You will be able to ask questions too. This process of receiving important research study information is known as informed consent.
If you are eligible and want to participate, you can begin participating in the research study. To find out more about what’s involved in participation, review the Research Study Schedule. You can change your mind about being in the research study at any point. You don’t have to give a reason for leaving.